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Monday, August 17, 2020 | History

3 edition of Pharmacological modification of the behavioral effects of cocaine found in the catalog.

Pharmacological modification of the behavioral effects of cocaine

Pharmacological modification of the behavioral effects of cocaine

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Published .
Written in English


Edition Notes

Statementby Kimberly Elizabeth Vanover.
Classifications
LC ClassificationsMicrofilm 93/653 (R)
The Physical Object
FormatMicroform
Paginationx, 160 leaves
Number of Pages160
ID Numbers
Open LibraryOL1050872M
LC Control Number93630098

  Non-pharmacological treatment options include environmental changes, bright-light treatment, and restraints and behavior modification. Pharmacological options involve the use of neuroleptics, benzodiazepines, and other agents such as beta-blocker therapy, carbamazepine, lithium, trazodone hydrochloride, and buspirone hydrochloride/5. Cocaine Anonymous and other step programs along with sober residences provide aftercare support to people in recovery from cocaine addiction. If you or someone you love is addicted to cocaine or crack, cocaine hotlines can provide more information about various treatment options.

The Impact of Crack Cocaine on Black America LaVelle Hendricks, EdD Assistant Professor Psychology, Counseling, and Special Education partners because of the drug’s libido-enhancing effects, recreational sex is less of a concern for open attitudes on the part of the patient toward behavioral changes, Size: KB.   Typically, pharmacological phenomena such as tolerance, sensitization, and dependence have been viewed as resulting from the operation of feedback mechanisms: pharmacologically disturbed homeostatic functioning is countered by compensatory responses that restore physiological by:

More than 23 million Americans have used cocaine at some time in their lives, and more than million are current cocaine users. Cocaine abuse and dependence affect all segments of society with devastating personal, social, and public health consequences. Unfortunately, effective cocaine pharmacotherapies are lacking. Pharmacodynamics refers to the relationship between drug concentration at the site of action and the resulting effect, including the time course and intensity of thera-peutic and adverse effects. The effect of a drug present at the site of action is determined by that drug’s binding with a receptor. Receptors may be present on neurons in.


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Pharmacological modification of the behavioral effects of cocaine Download PDF EPUB FB2

Cocaine abuse remains a major public health problem and contributes to many of our most disturbing social problems, including the spread of infectious disease, crime, violence, and neonatal drug exposure. Cocaine abuse results from a complex interplay of behavioral, pharmacological, and neurobiological : Hardcover.

PHARMACOLOGICAL MODIFICATION OF COCAINE AND APOMORPHINE SELF-ADMINISTRATION IN THE SQUIRREL MONKEY C. GILL, W. HOLZ, C. ZIRKLE and H. HILL Smith Kline & French Laboratories, Philadelphia, Pennsylvania, U.S.A.

Abstract Squirrel monkeys with intravenous catheters self-administered apomorphine and piribedil which have Cited by: The Neuroscience of Cocaine: Mechanisms and Treatment explores the complex effects Pharmacological modification of the behavioral effects of cocaine book this drug, addressing the neurobiology behind cocaine use and the psychosocial and behavioral factors that impact cocaine use and abuse.

This book provides researchers with an up-to-date understanding of the mechanisms behind cocaine use, and aids them in.

Behavioral Therapies for Drug Abuse and Dependence. The following sections present a brief overview of progress made in the development of effective behavioral treatments for drug abuse and dependence, with a primary focus on the broader categories of treatment that have been found to be effective in Stage II randomized clinical trials (including contingency management, Cited by: Read "Issues in the pharmacological modification of cocaine conditioning: evidence that the stimulus properties of drugs can interact with contextual cues to activate or inactivate cocaine conditioned stimuli, Behavioural Brain Research" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.

(Reprinted with permission from: R. Spealman and R. Kelleher,Behavioral effects of self-administered cocaine: responding maintained. Reviews the book Cocaine Abuse: Behavior, Pharmacology, and Clinical Applications, edited by Stephen T.

Higgins and Jonathan L. Katz (see record ). Although substantial advances have been made in behavioral and pharmacological treatments for addictions, moving treatment development to the next stage may require novel ways of approaching addictions, particularly those derived from new findings regarding of the neurobiological underpinnings of addictions, while assimilating and Cited by: Abstract.

The behavioral pharmacological characteristics of cocaine have been investigated in nonhumans and humans for several decades. Various experimental approaches have been utilized to explore the physiological, subjective, behavioral, and psychological effects of by: 6.

Several novel cocaine analogs, previously shown to be very potent in in vitro binding studies, have been examined for their stimulatory effects on locomotor activity and for their ability to displace [3H] binding in vivo in mice.

These compounds, likelack an ester link between the phenyl group and the tropane ring and have para Cited by: Includes information on mechanisms of brain action, treatment methods, health consequences, and prevention strategies for cocaine.

Extensive bibliography. Cocaine is a tropane alkaloid with central nervous systems (CNS) stimulating and local anesthetic activity. Cocaine binds to the dopamine, serotonin, and norepinephrine transport proteins and inhibits the re-uptake of dopamine, serotonin, and norepinephrine into pre-synaptic neurons.

This leads to an accumulation of the respective neurotransmitters in the synaptic cleft and may. “Dr. Platt has written a comprehensive review of the English-language literature on cocaine abuse His scholarship is impressive; he has reviewed more than 1, articles covering cocaine's history, use, pharmacology, behavioral effects, psychopathological and medical aspects, and treatment of abuse Dr.

Platt is an able writer and a talented summarizer.”Cited by: Facts about anti-addiction medications for alcoholism. Different pharmacological agents began to be explored more than 50 years ago to improve the efficacy of existing alcohol treatments, and. Abstract Rationale.

The illicit use of cocaine is a persistent health problem worldwide. Currently, there are no broadly effective pharmacotherapies to treat cocaine addiction.

A prerequisite for development of useful anti-cocaine medications is an understanding of the pharmacological basis of cocaine's effects. The functional analysis of behavior in laboratory Cited by: The drug self-administration model is based on the learning principle that behavior is maintained by its consequences, called reinforcers.

Laboratory animals (humans and nonhumans) will work to receive a range of different drugs administered orally, intramuscularly, intravenously, by smoking, or by insufflation.

Indeed, our lab and others have shown that dynamic changes occur during forced abstinence from cocaine in animal models, and that these changes can result in opposing effects of pharmacological challenge on cocaine abuse-related behavior depending on whether the manipulation occurs during active drug intake versus abstinence [54–56].

It Cited by: 2. In this book you will explore the brain and see what happens when drugs affect its functions. Filled with an array of useful definitions and amazing historic discoveries about the nervous system, this book will bring you up to speed on the brain/behavior relationship, basic neuroanatomy, neurophysiology, and the mechanistic actions of mood-altering drugs, including/5(4).

Behavioral approaches help engage people in drug abuse treatment, provide incentives for them to remain abstinent, modify their attitudes and behaviors related to drug abuse, and increase their life skills to handle stressful circumstances and environmental cues that may trigger intense craving for drugs and prompt another cycle of compulsive abuse.

The term behavioral addiction refers to a compulsion to engage in a natural reward – which is a behavior that is inherently rewarding (i.e., desirable or appealing) – despite adverse consequences.

Preclinical evidence has demonstrated that marked increases in the expression of ΔFosB through repetitive and excessive exposure to a natural reward induces the same Specialty: Psychiatry. Physical and Psychological Effects of Substance Use SUBSTANCE [and method of use] PHYSICAL/PSYCHOLOGICAL EFFECTS Alcohol Alcohol abuse is a pattern of problem drinking that results in health consequences, social, problems, or both.

However, alcohol dependence, or alcoholism, refers to a disease that is characterized by abnormal alcohol-File Size: 50KB.(+)-CPCA (nocaine, 3α-carbomethoxy-4β-(4-chlorophenyl)-N-methylpiperidine) is a stimulant drug similar in structure to pethidine (an opioid that possesses NDRI actions) and to RTI, but nocaine is lacking the two-carbon bridge of RTI's tropane skeleton.

This compound was first developed as a substitute agent for cocaine. Since this time a large number of substituted CAS Number:   Cocaine tolerance was assessed by comparing the acute effects of cocaine in drug-abstinent men who reported occasional cocaine use (n = 6) and in men who met DSM-III-R diagnostic criteria for.